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Rplp1tm1.2Melt
Targeted Allele Detail
Summary
Symbol: Rplp1tm1.2Melt
Name: ribosomal protein lateral stalk subunit P1; targeted mutation 1.1, Matilde E Lleonart
MGI ID: MGI:6094830
Synonyms: Rplp1delta
Gene: Rplp1  Location: Chr9:61820565-61821792 bp, - strand  Genetic Position: Chr9, 33.5 cM
Alliance: Rplp1tm1.2Melt page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:218949
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 1 through 3 floxed. (J:218949)
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
Not Specified
 
Phenotypes:
Affected Systems
show or hide all annotated terms Sex:
adipose tissue
abnormal adipose tissue development
digestive/alimentary system
abnormal intestine morphology
endocrine/exocrine glands
small thymus
growth/size/body
decreased birth body size
hematopoietic system
small thymus
impaired hematopoiesis
decreased erythroblast number
immune system
small thymus
integument
abnormal skin coloration
limbs/digits/tail
abnormal tail morphology
short tail
abnormal tail position or orientation
kinked tail
liver/biliary system
abnormal liver morphology
mortality/aging
postnatal lethality, incomplete penetrance
reproductive system
male infertility
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rplp1 Mutation:  7 strains or lines available
References
Original:  J:218949 Perucho L, et al., RPLP1, a crucial ribosomal protein for embryonic development of the nervous system. PLoS One. 2014;9(6):e99956
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory