Rhoq^tm1.1Pkm
Targeted Allele Detail

Summary

• Symbol: Rhoq^tm1.1Pkm
• Name: ras homolog family member Q; targeted mutation 1.1, Pieta Mattila
• MGI ID: MGI:6095179
• Synonyms: TC10 floxed
• Gene: Rhoq Location: Chr17:87270539-87307497 bp, + strand Genetic Position: Chr17, 56.9 cM
• Alliance: Rhoq^tm1.1Pkm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:248522
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The selection cassette contains an FRT-flanked neomycin cassette, followed by a 3' loxP site inserted downstream of exon 2, and another loxP site inserted upstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 2 floxed. (J:101977, J:248522)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rhoq Mutation: 16 strains or lines available

References

• Original: J:248522 Burbage M, et al., The Small Rho GTPase TC10 Modulates B Cell Immune Responses. J Immunol. 2017 Sep 1;199(5):1682-1695
• All: 2 reference(s)