Igfn1^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igfn1^em1(IMPC)J
• Name: immunoglobulin-like and fibronectin type III domain containing 1; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6095183
• Gene: Igfn1 Location: Chr1:135881316-135934080 bp, - strand Genetic Position: Chr1, 59.44 cM
• Alliance: Igfn1^em1(IMPC)J page
• IMPC: Igfn1 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences CATGGGTAGAAACAGCTGCA, GGATGAATAGTCCCAACTGT, GCAGGGAAGAAGCAACATAG and GCCTGACTTCCATCATGCAG, which resulted in a 464 bp deletion beginning at Chromosome 1 negative strand position 135,980,217 bp and ending after 135,979,754 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000820624 (exon 7) and 324 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 200 and early truncation 32 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Igfn1 Mutation: 136 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)