Tnni3k^tm1.1Tfo
Targeted Allele Detail

Summary

• Symbol: Tnni3k^tm1.1Tfo
• Name: TNNI3 interacting kinase; targeted mutation 1.1, Thomas Force
• MGI ID: MGI:6098722
• Gene: Tnni3k Location: Chr3:154491928-154761044 bp, - strand Genetic Position: Chr3, 79.32 cM
• Alliance: Tnni3k^tm1.1Tfo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249318
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intergenic deletion
• Mutation details: The targeting vector contains loxP sites flanking exons 1 and 2 and a neomycin selection cassette. Germline cre-mediated recombination removed exons 1 and 2 and the neo cassette. (J:213546)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnni3k Mutation: 47 strains or lines available

References

• Original: J:213546 Vagnozzi RJ, et al., Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart. Sci Transl Med. 2013 Oct 16;5(207):207ra141
• All: 6 reference(s)