Lrrc8c^tm1Maim
Targeted Allele Detail

Summary

• Symbol: Lrrc8c^tm1Maim
• Name: leucine rich repeat containing 8 family, member C; targeted mutation 1, Masayoshi Imagawa
• MGI ID: MGI:6099025
• Synonyms: fad158^-
• Gene: Lrrc8c Location: Chr5:105667254-105760884 bp, + strand Genetic Position: Chr5, 50.68 cM
• Alliance: Lrrc8c^tm1Maim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247160
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The fourth exon, encoding most of the open reading frame, was replaced with a neomycin selection cassette. Q-PCR analysis on samples from various tissues confirmed that the homozygous mice did not express transcript from this allele. (J:247160)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Lrrc8c Mutation: 46 strains or lines available

References

• Original: J:247160 Hayashi T, et al., Factor for adipocyte differentiation 158 gene disruption prevents the body weight gain and insulin resistance induced by a high-fat diet. Biol Pharm Bull. 2011;34(8):1257-63
• All: 3 reference(s)