Clrn1^tm1.1Ugpa
Targeted Allele Detail

Summary

• Symbol: Clrn1^tm1.1Ugpa
• Name: clarin 1; targeted mutation 1.1, Unite de Genetique et Physiologie de l'Audition, Institut Pasteur
• MGI ID: MGI:6099051
• Synonyms: Clrn1^ex4fl, Clrn1-floxed
• Gene: Clrn1 Location: Chr3:58751449-58792633 bp, - strand Genetic Position: Chr3, 28.78 cM
• Alliance: Clrn1^tm1.1Ugpa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:265318
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and a second loxP site and FRT-flanked neomycin selection cassette were inserted downstream of exon 4 via homologous recombination. Exon 4 remained flanked by loxP sites following excision of the FRT-flanked neomycin cassette. (J:265318)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clrn1 Mutation: 17 strains or lines available

References

• Original: J:265318 Dulon D, et al., Clarin-1 gene transfer rescues auditory synaptopathy in model of Usher syndrome. J Clin Invest. 2018 Aug 1;128(8):3382-3401
• All: 1 reference(s)