Kctd16^tm1.1Bet
Targeted Allele Detail

Summary

• Symbol: Kctd16^tm1.1Bet
• Name: potassium channel tetramerisation domain containing 16; targeted mutation 1.1, Bernhard Bettler
• MGI ID: MGI:6099097
• Gene: Kctd16 Location: Chr18:40389358-40680311 bp, + strand Genetic Position: Chr18, Syntenic
• Alliance: Kctd16^tm1.1Bet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249700
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted to flank exon 1. A neomycin selection cassette was inserted into intron 1, downstream of the loxP site. Cre-mediated recombination resulted in the deletion of exon 1. Western blot analysis of whole brain lysates showed that no detectable protein is expressed from this allele. (J:249700)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kctd16 Mutation: 33 strains or lines available

References

• Original: J:249700 Cathomas F, et al., Behavioural endophenotypes in mice lacking the auxiliary GABAB receptor subunit KCTD16. Behav Brain Res. 2017 Jan 15;317:393-400
• All: 3 reference(s)