Tg(Acta2-cre)1Rkl
Transgene Detail

Summary

• Symbol: Tg(Acta2-cre)1Rkl
• Name: transgene insertion 1, Raghu Kalluri
• MGI ID: MGI:6101504
• Synonyms: aSMA-Cre
• Transgene: Tg(Acta2-cre)1Rkl Location: unknown
• Alliance: Tg(Acta2-cre)1Rkl page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Acta2-cre)1Rkl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Acta2 (MGI:87909)

• Mutation details: The aSMA-cre transgenic construct containing the Cre recombinase gene under control of an extended 5.2kb mouse Acta2 (actin, alpha 2, smooth muscle, aorta) gene promoter that includes the Acta2 promoter plus exon 1, intron 1, and part of exon 2, was microinjected into FVB fertilized mouse eggs. The founder line 1 was subsequently established. (J:101977, J:200001)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Acta2 (mouse) Summary of all recombinase alleles driven by Acta2. Comparative matrix view of recombinase activities Alliance mouse Acta2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:200001 Lebleu VS, et al., Origin and function of myofibroblasts in kidney fibrosis. Nat Med. 2013 Aug;19(8):1047-53
• All: 18 reference(s)