Esr1^{tm1.1(icre)Jako}
Targeted Allele Detail

Summary

• Symbol: Esr1^{tm1.1(icre)Jako}
• Name: estrogen receptor 1 (alpha); targeted mutation 1.1, CheMyong Ko
• MGI ID: MGI:6102905
• Synonyms: Esr1-iCre
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^{tm1.1(icre)Jako} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250442
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Esr1^{tm1.1(icre)Jako} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Esr1 (MGI:1352467)

• Mutation details: A targeting vector containing iCre (codon-improved Cre recombinase), a polyadenylation sequence, and an FRT site flanked PGK-NEO cassette was inserted upstream of the initiation codon site of exon 2 of the the Esr1 gene of a BAC clone (ID RP23-7D5). Flp-mediated recombination removed the FRT-flanked neo cassette. (J:250442)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Esr1 (mouse) Summary of all recombinase alleles driven by Esr1. Alliance mouse Esr1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 68 strains or lines available

References

• Original: J:250442 Park CJ, et al., Generation and characterization of an estrogen receptor alpha-iCre knock-in mouse. Genesis. 2017 Dec;55(12)
• All: 2 reference(s)