Fndc4^tm1.1Mabo
Targeted Allele Detail

Summary

• Symbol: Fndc4^tm1.1Mabo
• Name: fibronectin type III domain containing 4; targeted mutation 1.1, Madeleen Bosma
• MGI ID: MGI:6103906
• Gene: Fndc4 Location: Chr5:31449589-31453279 bp, - strand Genetic Position: Chr5, 17.27 cM
• Alliance: Fndc4^tm1.1Mabo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236896
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted into introns 1 and 5. Exons 2-5 were deleted through subsequent cre-mediated recombination. (J:236896)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fndc4 Mutation: 9 strains or lines available

References

• Original: J:236896 Bosma M, et al., FNDC4 acts as an anti-inflammatory factor on macrophages and improves colitis in mice. Nat Commun. 2016 Apr 12;7:11314
• All: 1 reference(s)