Moap1^tm1Vcy
Targeted Allele Detail

Summary

• Symbol: Moap1^tm1Vcy
• Name: modulator of apoptosis 1; targeted mutation 1, Victor C Yu
• MGI ID: MGI:6104254
• Gene: Moap1 Location: Chr12:102708489-102709920 bp, - strand Genetic Position: Chr12, 52.14 cM
• Alliance: Moap1^tm1Vcy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238373
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2, containing the entire coding region, was replaced with a neomycin resistance gene cassette, creating a null allele. RT-PCR and western blot experiments confirmed the lack of expression from this allele in liver and MEFs. (J:238373)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Moap1 Mutation: 28 strains or lines available

References

• Original: J:238373 Tan CT, et al., MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria. Cell Rep. 2016 Jun 28;16(1):174-85
• All: 4 reference(s)