Mlc1^tm1.1Vdk
Targeted Allele Detail

Summary

• Symbol: Mlc1^tm1.1Vdk
• Name: megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human); targeted mutation 1.1, Marjo S van der Knaap
• MGI ID: MGI:6105932
• Synonyms: Tg(Mlc1-Egfp)
• Gene: Mlc1 Location: Chr15:88840087-88863192 bp, - strand Genetic Position: Chr15, 44.46 cM
• Alliance: Mlc1^tm1.1Vdk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250520
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with the coding region of the enhanced green fluorescent protein reporter gene via homologous recombination. An inserted loxP flanked neo expression cassette was removed via cre-mediated recombination. (J:250520)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlc1 Mutation: 28 strains or lines available

References

• Original: J:250520 Dubey M, et al., Mice with megalencephalic leukoencephalopathy with cysts: a developmental angle. Ann Neurol. 2015 Jan;77(1):114-31
• All: 5 reference(s)