Lamb1^Lt
Spontaneous Allele Detail

Summary

• Symbol: Lamb1^Lt
• Name: laminin B1; Lamb1-truncated
• MGI ID: MGI:6107689
• Synonyms: lamb1t, Lamb1^tr57
• Gene: Lamb1 Location: Chr12:31315233-31379643 bp, + strand Genetic Position: Chr12, 13.39 cM
• Alliance: Lamb1^Lt page

Mutation origin

• Strain of Origin: B6N.129(Cg)-Fxyd2^tm1Kdr

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Single point mutation
• This spontaneous T-to-A mutation changes leucine codon 1778 into a premature stop codon (p.L1778*). (J:247484)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lamb1 Mutation: 82 strains or lines available

Notes

Arose on B6N.129(Cg)-Fxyd2^tm1Kdr mice.

References

• Original: J:247484 Liu YB, et al., A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin beta1 subunit, Lamb1. Elife. 2015 Dec 24;4:e11102
• All: 1 reference(s)