Hcfc2^em1Btlr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Hcfc2^em1Btlr
• Name: host cell factor C2; endonuclease-mediated mutation 1, Bruce Beutler
• MGI ID: MGI:6108107
• Gene: Hcfc2 Location: Chr10:82531994-82578262 bp, + strand Genetic Position: Chr10, 39.93 cM
• Alliance: Hcfc2^em1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Not Specified
• TALEN targeting was used to generate a knock-out allele. (J:251008)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hcfc2 Mutation: 33 strains or lines available

References

• Original: J:251008 Sun L, et al., HCFC2 is needed for IRF1- and IRF2-dependent Tlr3 transcription and for survival during viral infections. J Exp Med. 2017 Nov 06;214(11):3263-3277
• All: 1 reference(s)