Shprh^tm1Jhjh
Targeted Allele Detail

Summary

• Symbol: Shprh^tm1Jhjh
• Name: SNF2 histone linker PHD RING helicase; targeted mutation 1, Jan H J Hoeijmakers
• MGI ID: MGI:6108184
• Gene: Shprh Location: Chr10:11025171-11093339 bp, + strand Genetic Position: Chr10, 3.66 cM
• Alliance: Shprh^tm1Jhjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177630
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene cassette replaced exons 9 and 10. Immunoblots confirm the lack of expression of wild-type peptide from this allele. (J:177630)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shprh Mutation: 85 strains or lines available

References

• Original: J:177630 Krijger PH, et al., HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase. DNA Repair (Amst). 2011 Apr 3;10(4):438-44
• All: 1 reference(s)