Myh10^ehc
Chemically induced Allele Detail

Summary

• Symbol: Myh10^ehc
• Name: myosin, heavy polypeptide 10, non-muscle; embryonic hydrocephalus and cardiac defects
• MGI ID: MGI:6108305
• Synonyms: Myh10^l11Jus27.1
• Gene: Myh10 Location: Chr11:68582385-68707458 bp, + strand Genetic Position: Chr11, 41.95 cM, cytoband B3
• Alliance: Myh10^ehc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to T in the splice donor site following exon 18 that results in skipping of the exon and protein truncation (1-703). THe predicted truncated protein lacks the coiled coil rod domain and undetectable on western blots with the C-terminal NMHC IIB antibody. (J:248868)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myh10 Mutation: 95 strains or lines available

Notes

This mutation was one of two identified in l11Jus27.

References

• Original: J:248868 Ridge LA, et al., Non-muscle myosin IIB (Myh10) is required for epicardial function and coronary vessel formation during mammalian development. PLoS Genet. 2017 Oct;13(10):e1007068
• All: 1 reference(s)