Tg(CAG-Fgfr3*K650E,-EGFP)10Jheb
Transgene Detail
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Symbol: |
Tg(CAG-Fgfr3*K650E,-EGFP)10Jheb |
Name: |
transgene insertion 10, Jean Hebert |
MGI ID: |
MGI:6108317 |
Synonyms: |
FGFR3-GOF |
Transgene: |
Tg(CAG-Fgfr3*K650E,-EGFP)10Jheb Location: unknown
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Alliance: |
Tg(CAG-Fgfr3*K650E,-EGFP)10Jheb page
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Transgene Type: |
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Transgenic (Conditional ready, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Tg(CAG-Fgfr3*K650E,-EGFP)10Jheb expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Fgfr3 (MGI:95524) |
Fgfr3*K650E |
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Mutation details: The transgenic construct was designed with a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (CAG), a loxP-flanked STOP cassette, the mouse Fgfr3 (fibroblast growth factor receptor 3) cDNA containing a lysine to glutamic acid substitution at residue 650 (K650E) rendering Fgfr3 constitutively active, followed by an IRES-eGFP fluorescent protein sequence.
(J:212260)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:212260 Kang W, et al., Astrocyte activation is suppressed in both normal and injured brain by FGF signaling. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2987-95 |
All: |
3 reference(s) |
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