Trmu^tm1.1Tomik
Targeted Allele Detail

Summary

• Symbol: Trmu^tm1.1Tomik
• Name: tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase; targeted mutation 1.1, Kazuhito Tomizawa
• MGI ID: MGI:6108879
• Synonyms: Mtu1^-
• Gene: Trmu Location: Chr15:85763513-85781595 bp, + strand Genetic Position: Chr15, 40.42 cM
• Alliance: Trmu^tm1.1Tomik page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235644
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: LoxP sites were inserted into introns 1 and 2. Exon 2 was deleted through subsequent Cre-mediated recombination, creating a null allele. (J:235644)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trmu Mutation: 20 strains or lines available

References

• Original: J:235644 Wu Y, et al., Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. PLoS Genet. 2016 Sep;12(9):e1006355
• All: 1 reference(s)