Ythdc2tm1b(EUCOMM)Hmgu
Targeted Allele Detail
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Symbol: |
Ythdc2tm1b(EUCOMM)Hmgu |
Name: |
YTH domain containing 2; targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH |
MGI ID: |
MGI:6110119 |
Gene: |
Ythdc2 Location: Chr18:44961521-45022782 bp, + strand Genetic Position: Chr18, 23.81 cM
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Alliance: |
Ythdc2tm1b(EUCOMM)Hmgu page
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IMPC: |
Ythdc2 gene page |
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Mutant Cell Line: |
HEPD0563_8_G03 |
Germline Transmission: |
Earliest citation of germline transmission:
J:253477
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Parent Cell Line: |
JM8A1.N3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutations: |
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Insertion, Intragenic deletion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 44972828 of Chromosome 18 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 44974773. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s).
(J:253477)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ythdc2 Mutation: |
60 strains or lines available
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Original: |
J:253477 Bailey AS, et al., The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline. Elife. 2017 Oct 31;6:e26116 |
All: |
1 reference(s) |
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