Nmb^tm1Zfc
Targeted Allele Detail

Summary

• Symbol: Nmb^tm1Zfc
• Name: neuromedin B; targeted mutation 1, Zhou-Feng Chen
• MGI ID: MGI:6110562
• Gene: Nmb Location: Chr7:80551975-80554810 bp, - strand Genetic Position: Chr7, 45.71 cM, cytoband D2
• Alliance: Nmb^tm1Zfc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253572
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with an eGFP-IRES-rtTA-ACN expression cassette. eGFP was fused in frame to the first coding exon. However, eGFP fluorescence was not detectable in heterozygous nor homozygous mutant mice. In situ hybridization experiments showed that transcripts were absent in dorsal root ganglia of homozygous mice. (J:253572)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nmb Mutation: 9 strains or lines available

References

• Original: J:253572 Wan L, et al., Distinct roles of NMB and GRP in itch transmission. Sci Rep. 2017 Nov 13;7(1):15466
• All: 2 reference(s)