Tg(CAG-Bmp4,-EGFP)1Ypc
Transgene Detail

Summary

• Symbol: Tg(CAG-Bmp4,-EGFP)1Ypc
• Name: transgene insertion 1, YiPing Chen
• MGI ID: MGI:6110825
• Synonyms: pMes-Bmp4
• Transgene: Tg(CAG-Bmp4,-EGFP)1Ypc Location: unknown
• Alliance: Tg(CAG-Bmp4,-EGFP)1Ypc page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(CAG-Bmp4,-EGFP)1Ypc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Bmp4 (MGI:88180)

• Mutation details: The transgene consists of the chicken beta-actin promoter and the CMV immediate-early enhancer, a loxP flanked STOP cassette, and the full-length mouse Bmp4 cDNA followed by an Ires-EGFP sequences. Excision of the STOP cassette by cre recombinase permits expression of Bmp4. Five lines were generated: 1, 2, 3, 4, and 5. (J:214763)

Disease models

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:214763 He F, et al., Directed Bmp4 expression in neural crest cells generates a genetic model for the rare human bony syngnathia birth defect. Dev Biol. 2014 Jul 15;391(2):170-81
• All: 2 reference(s)