Tg(TTR*L55P)#Jbux
Transgene Detail

Summary

• Symbol: Tg(TTR*L55P)#Jbux
• Name: transgene insertion, Joel Buxbaum
• MGI ID: MGI:6110834
• Transgene: Tg(TTR*L55P)#Jbux Location: unknown
• Alliance: Tg(TTR*L55P)#Jbux page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(TTR*L55P)#Jbux expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ttr (MGI:98865)

• Mutation details: This transgene consists of the human transthyretin gene containing a single base substitution, T to C, in exon 3 corresponding to a leucine to proline amino acid substitution at position 55 under the control of the endogenous promoter. This line carries a single copy of the mutant gene. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:68458)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:68458 Teng MH, et al., Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: a possible model for senile systemic amyloidosis. (Erratum: 2002; 82(3):241). Lab Invest. 2001 Mar;81(3):385-96
• All: 1 reference(s)