Tent5c^em1Adki
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tent5c^em1Adki
• Name: terminal nucleotidyltransferase 5C; endonuclease-mediated mutation 1, Andrzej Dziembowski
• MGI ID: MGI:6111077
• Gene: Tent5c Location: Chr3:100375373-100396508 bp, - strand Genetic Position: Chr3, 43.71 cM
• Alliance: Tent5c^em1Adki page

Mutation origin

• Strain of Origin: (C57BL/6JTar x CBA/WTar)F1

Mutation description

• Allele Type: Endonuclease-mediated (Epitope tag, Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR guides targeted the catalytic domain to create a FLAG-tagged knockout by deleting 17 bp and inserting 301 bp creating a frameshift at C88 and premature termination (1-26). (J:252302)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tent5c Mutation: 22 strains or lines available

References

• Original: J:252302 Mroczek S, et al., The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma. Nat Commun. 2017 Sep 20;8(1):619
• All: 4 reference(s)