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Rufy3tm1.1Migar
Targeted Allele Detail
Summary
Symbol: Rufy3tm1.1Migar
Name: RUN and FYVE domain containing 3; targeted mutation 1.1, Michihirio Igarashi
MGI ID: MGI:6111136
Gene: Rufy3  Location: Chr5:88712899-88799251 bp, + strand  Genetic Position: Chr5, 43.77 cM
Alliance: Rufy3tm1.1Migar page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:253649
Parent Cell Line:  RENKA (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsAn FRT site flanked pgk-Neo cassette and a loxP sequence were inserted 249 bp upstream of exon 3, and a second loxP sequence 269 bp downstream of exon 3. Exon 3 was subsequently deleted via Cre-mediated recombination. Western blot analysis showed that no detectable encoded protein was expressed from this allele. (J:253649)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rufy3 Mutation:  37 strains or lines available
References
Original:  J:253649 Honda A, et al., Rufy3 is an adapter protein for small GTPases that activates a Rac guanine nucleotide exchange factor to control neuronal polarity. J Biol Chem. 2017 Dec 22;292(51):20936-20946
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory