Myo9a^tm1.2Bah
Targeted Allele Detail

Summary

• Symbol: Myo9a^tm1.2Bah
• Name: myosin IXa; targeted mutation 1.2, Martin Bahler
• MGI ID: MGI:6111331
• Gene: Myo9a Location: Chr9:59658179-59836149 bp, + strand Genetic Position: Chr9, 32.13 cM
• Alliance: Myo9a^tm1.2Bah page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:251454
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated recombination of loxP sites surrounding exon 2, which includes part of the 5' UTR and codes for the N-terminal 280 of 2542 amino acids of the protein, resulted in the removal of this exon in the germline. Expression of the encoded protein was shown to be abolished by Western blot analysis of protein extracts derived from homozygous mutant mice. (J:251454)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo9a Mutation: 114 strains or lines available

References

• Original: J:251454 Abouhamed M, et al., Myosin IXa regulates epithelial differentiation and its deficiency results in hydrocephalus. Mol Biol Cell. 2009 Dec;20(24):5074-85
• All: 3 reference(s)