AU040320^{tm1b(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: AU040320^{tm1b(EUCOMM)Wtsi}
• Name: expressed sequence AU040320; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:6111779
• Synonyms: AU040320-, AU040320-del, AU040320 KO
• Gene: AU040320 Location: Chr4:126647331-126763487 bp, + strand Genetic Position: Chr4, 60.94 cM
• Alliance: AU040320^{tm1b(EUCOMM)Wtsi} page
• IMPC: AU040320 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249823
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 126685053 of Chromosome 4 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 3 at position 126686435. Exon 3 is thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked exon 3. (J:249823)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any AU040320 Mutation: 60 strains or lines available

References

• Original: J:249823 Guidi LG, et al., Knockout Mice for Dyslexia Susceptibility Gene Homologs KIAA0319 and KIAA0319L have Unaffected Neuronal Migration but Display Abnormal Auditory Processing. Cereb Cortex. 2017 Dec 1;27(12):5831-5845
• All: 2 reference(s)