Kctd13^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Kctd13^{tm1.1(KOMP)Vlcg}
• Name: potassium channel tetramerisation domain containing 13; targeted mutation 1.1, Velocigene
• MGI ID: MGI:6111982
• Synonyms: Kctd13 KO
• Gene: Kctd13 Location: Chr7:126528051-126544781 bp, + strand Genetic Position: Chr7, 69.25 cM
• Alliance: Kctd13^{tm1.1(KOMP)Vlcg} page
• IMPC: Kctd13 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250125
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A Velocigene cassette ZEN-Ub1 replaced a genomic region of size 16081bp between positions 134072572-134088652 of Chromosome 7 (Genome Build37). The hUBCpro-neo-p(A) cassette was removed via cre-mediated recombination. Western blot analysis confirmed complete loss of protein expression in various brain regions (hippocampus, cortex, cerebellum and midbrain) from homozygous mutant mice and a ~50% reduction in heterozygotes. (J:250125)

Expression

In Mice Carrying this Mutation:	61 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kctd13 Mutation: 14 strains or lines available

References

• Original: J:250125 Escamilla CO, et al., Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature. 2017 Nov 9;551(7679):227-231
• All: 1 reference(s)