Cacna2d1^tm1.1Gfng
Targeted Allele Detail

Summary

• Symbol: Cacna2d1^tm1.1Gfng
• Name: calcium channel, voltage-dependent, alpha2/delta subunit 1; targeted mutation 1.1, Guoping Feng
• MGI ID: MGI:6112588
• Synonyms: Cav alpha2 delta1 CKO
• Gene: Cacna2d1 Location: Chr5:16139786-16579502 bp, + strand Genetic Position: Chr5, 6.56 cM
• Alliance: Cacna2d1^tm1.1Gfng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235023
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin selection cassette and a loxP site was inserted downstream of exon 6 of the targeted gene another loxP site was inserted upstream of exon 6. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 6 floxed. (J:235023)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cacna2d1 Mutation: 80 strains or lines available

References

• Original: J:235023 Park J, et al., Central Mechanisms Mediating Thrombospondin-4-induced Pain States. J Biol Chem. 2016 Jun 17;291(25):13335-48
• All: 11 reference(s)