Nfkb1^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nfkb1^m2Btlr
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105; mutation 2, Bruce Beutler
• MGI ID: MGI:6113387
• Synonyms: kookaburra
• Gene: Nfkb1 Location: Chr3:135290416-135397308 bp, - strand Genetic Position: Chr3, 62.82 cM
• Alliance: Nfkb1^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced A to T transversion at base pair 135,626,611 (v38) on chromosome 3, corresponding to base pair 65,372 in the GenBank genomic region NC_000069. The mutation corresponds to residue 884 in the mRNA sequence NM_178666 within exon 7 of 25 total exons. The mutation results in substitution of lysine 128 for a premature stop codon (K128*) in the protein. (J:254822)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkb1 Mutation: 102 strains or lines available

References

• Original: J:254822 Zhong X, et al., Mutagenetix entry for kookaburra. MGI Direct Data Submission. 2018
• All: 1 reference(s)