Itk^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Itk^m2Btlr
• Name: IL2 inducible T cell kinase; mutation 2, Bruce Beutler
• MGI ID: MGI:6113416
• Synonyms: goodnow
• Gene: Itk Location: Chr11:46215977-46280342 bp, - strand Genetic Position: Chr11, 27.75 cM
• Alliance: Itk^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to G transversion at base pair 46,338,099 (v38) on chromosome 11, or base pair 51,417 in the GenBank genomic region NC_000076 within the donor splice site of intron 12. The effect of the mutation at the cDNA and protein levels have not examined, but the mutation is predicted to result in the use of a cryptic site in intron 12. The resulting transcript would have a 5-base pair insertion of intron 12, causing a frame shifted protein product beginning after amino acid 410 of the protein, which is normally 619 amino acids in length. (J:254826)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itk Mutation: 50 strains or lines available

References

• Original: J:254826 Zhong X, et al., Mutagenetix entry for goodnow. MGI Direct Data Submission. 2018
• All: 1 reference(s)