Zap70^m6Btlr
Chemically induced Allele Detail

Summary

• Symbol: Zap70^m6Btlr
• Name: zeta-chain (TCR) associated protein kinase; mutation 6, Bruce Beutler
• MGI ID: MGI:6113448
• Synonyms: wanna4
• Gene: Zap70 Location: Chr1:36800912-36821899 bp, + strand Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
• Alliance: Zap70^m6Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to A transversion at base pair 36,781,365 (v38) on chromosome 1, or base pair 19,568 in the GenBank genomic region NC_000067. The mutation corresponds to residue 1,802 in the mRNA sequence NM_001289766 within exon 12 of 13 total exons. The mutation results in a valine to aspartic acid substitution at position 547 (V547D) in the protein. (J:254831)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zap70 Mutation: 55 strains or lines available

References

• Original: J:254831 Zhong X, et al., Mutagenetix entry for wanna4. MGI Direct Data Submission. 2018
• All: 1 reference(s)