Kiss1^{tm2(cre/GFP)Coll}
Targeted Allele Detail

Summary

• Symbol: Kiss1^{tm2(cre/GFP)Coll}
• Name: KiSS-1 metastasis-suppressor; targeted mutation 2, William H Colledge
• MGI ID: MGI:6113450
• Synonyms: Kiss1-Cre:GFP, Kiss1^CRE-GFP, Kiss1^{tm2(Cre-GFP)Coll}
• Gene: Kiss1 Location: Chr1:133254950-133257460 bp, + strand Genetic Position: Chr1, 57.91 cM
• Alliance: Kiss1^{tm2(cre/GFP)Coll} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254977
• Parent Cell Line: CCB (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase, Reporter)
• Mutations: Insertion, Intragenic deletion
• Kiss1^{tm2(cre/GFP)Coll} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Kiss1 (MGI:2663985)

• Mutation details: A targeting vector was designed to insert the cre/GFP fusion gene with a neo cassette in exon 2 of the mouse Kiss1 gene such that ATG of the cre/GFP fusion gene was kept in frame located 11 codons downstream of the Kiss1 ATG. The absence of protein was confirmed in mutant mice. (J:254977)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Kiss1 (mouse) Summary of all recombinase alleles driven by Kiss1. Comparative matrix view of recombinase activities Alliance mouse Kiss1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Kiss1 Mutation: 22 strains or lines available

References

• Original: J:254977 Yeo SH, et al., Visualisation of Kiss1 Neurone Distribution Using a Kiss1-CRE Transgenic Mouse. J Neuroendocrinol. 2016 Nov;28(11)
• All: 14 reference(s)