Dennd1b^tm1.1Achn
Targeted Allele Detail

Summary

• Symbol: Dennd1b^tm1.1Achn
• Name: DENN domain containing 1B; targeted mutation 1.1, Andrew C Chan
• MGI ID: MGI:6113475
• Synonyms: Dennd1b^loxp
• Gene: Dennd1b Location: Chr1:138891447-139103781 bp, + strand Genetic Position: Chr1, 60.84 cM
• Alliance: Dennd1b^tm1.1Achn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:229307
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and an frt-flanked neomycin selection cassette were inserted 5' to exon 6 and a single loxP site was inserted 3' to exon 6. The neomycin selection cassette was removed in the germline via Flp recombination in the final conditional allele, leaving loxP sites flanking exon 6. (J:229307)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dennd1b Mutation: 65 strains or lines available

References

• Original: J:229307 Yang CW, et al., Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease. Cell. 2016 Jan 14;164(1-2):141-55
• All: 1 reference(s)