Tbx18^{tm3.1(cre/ERT2)Sev}
Targeted Allele Detail

Summary

• Symbol: Tbx18^{tm3.1(cre/ERT2)Sev}
• Name: T-box18; targeted mutation 3.1, Sylvia Evans
• MGI ID: MGI:6113477
• Synonyms: Tbx18-CreERT2
• Gene: Tbx18 Location: Chr9:87584853-87613313 bp, - strand Genetic Position: Chr9, 47.06 cM, cytoband E3.2
• Alliance: Tbx18^{tm3.1(cre/ERT2)Sev} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253913
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tbx18^{tm3.1(cre/ERT2)Sev} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tbx18 (MGI:1923615)

• Mutation details: A Cre/ERT2_FRT_PGK-Neo_FRT cassette was inserted into the Tbx18 locus, 6 base pairs downstream of the endogenous ATG. The neo cassette was removed by FLP mediated recombination. (J:253913)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx18 (mouse) Summary of all recombinase alleles driven by Tbx18. Alliance mouse Tbx18 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbx18 Mutation: 36 strains or lines available

References

• Original: J:253913 Guimaraes-Camboa N, et al., Pericytes of Multiple Organs Do Not Behave as Mesenchymal Stem Cells In Vivo. Cell Stem Cell. 2017 Mar 2;20(3):345-359.e5
• All: 10 reference(s)