Trp53bp1^m3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Trp53bp1^m3Btlr
• Name: transformation related protein 53 binding protein 1; mutation 3, Bruce Beutler
• MGI ID: MGI:6113492
• Synonyms: concur
• Gene: Trp53bp1 Location: Chr2:121023762-121101888 bp, - strand Genetic Position: Chr2, 60.37 cM
• Alliance: Trp53bp1^m3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T-to-A transversion at base pair 121,270,319 (GRCm38) on chromosome 2, or base pair 20,007 in the GenBank genomic region NC_000068 within intron 2 (10 base pairs from exon 3). The effect of the mutation at the cDNA and protein levels has not been examined, but the mutation is predicted to result in the use of a cryptic site in intron 2. The resulting transcript would have a 60-base pair insertion of intron 2, which would cause an in-frame insertion of 19 aberrant amino acids beginning after amino acid 64. (J:254848)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53bp1 Mutation: 100 strains or lines available

References

• Original: J:254848 Choi JH, et al., Mutagenetix entry for concur. MGI Direct Data Submission. 2018
• All: 1 reference(s)