Map3k8^M4Btlr
Chemically induced Allele Detail

Summary

• Symbol: Map3k8^M4Btlr
• Name: mitogen-activated protein kinase kinase kinase 8; mutation 4, Bruce Beutler
• MGI ID: MGI:6113556
• Synonyms: Flojo
• Gene: Map3k8 Location: Chr18:4331325-4352978 bp, - strand Genetic Position: Chr18, 2.73 cM
• Alliance: Map3k8^M4Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to A transversion at base pair 4,339,548 (v38) on chromosome 18, or base pair 13,865 in the NC_000084 GenBank genomic region. The mutation corresponds to residue 946 in the mRNA sequence NM_008713 within exon 5 of 8 total exons. The mutation results in a serine to arginine substitution at position 274 (S274R) in the protein. (J:254880)
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k8 Mutation: 41 strains or lines available

References

• Original: J:254880 Zhang Z, et al., Mutagenetix entry for Flojo. MGI Direct Data Submission. 2018
• All: 1 reference(s)