Tnik^tm1Teya
Targeted Allele Detail

Summary

• Symbol: Tnik^tm1Teya
• Name: TRAF2 and NCK interacting kinase; targeted mutation 1, Tesshi Yamada
• MGI ID: MGI:6113591
• Gene: Tnik Location: Chr3:28317362-28724734 bp, + strand Genetic Position: Chr3, 11.92 cM
• Alliance: Tnik^tm1Teya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241611
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette driven by the phosphoglycerate kinase (PGK) promoter replaced exon 4 via homologous recombination. This deletion is expected to remove almost the entire kinase domain (amino acid residues 25-289) including the ATP-binding site. (J:241611)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnik Mutation: 77 strains or lines available

References

• Original: J:241611 Masuda M, et al., TNIK inhibition abrogates colorectal cancer stemness. Nat Commun. 2016 Aug 26;7:12586
• All: 1 reference(s)