Tmem35a^{tm1.1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Tmem35a^{tm1.1(KOMP)Vlcg}
• Name: transmembrane protein 35A; targeted mutation 1.1, Velocigene
• MGI ID: MGI:6113597
• Synonyms: NACHO KO, tmem35 KO
• Gene: Tmem35a Location: ChrX:133195974-133206718 bp, + strand Genetic Position: ChrX, 56.06 cM
• Alliance: Tmem35a^{tm1.1(KOMP)Vlcg} page
• IMPC: Tmem35a gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244268
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 (containing the lacZ reporter gene and a loxP site flanked neomycin resistance gene cassette) created a deletion of size 9360bp between positions 130830034-130839393 of Chromosome X (Genome Build37). This deletes most of the two-exon coding region. The neo cassette was removed through subsequent cre-mediated recombination. (J:244268)

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem35a Mutation: 5 strains or lines available

References

• Original: J:244268 Kennedy BC, et al., Deletion of novel protein TMEM35 alters stress-related functions and impairs long-term memory in mice. Am J Physiol Regul Integr Comp Physiol. 2016 Jul 01;311(1):R166-78
• All: 4 reference(s)