Pvalb^{tm1.1(Ncre)Mdes}
Targeted Allele Detail

Summary

• Symbol: Pvalb^{tm1.1(Ncre)Mdes}
• Name: parvalbumin; targeted mutation 1.1, Martin Deschenes
• MGI ID: MGI:6113615
• Synonyms: Pv-CreN
• Gene: Pvalb Location: Chr15:78075314-78090600 bp, - strand Genetic Position: Chr15, 36.93 cM, cytoband E
• Alliance: Pvalb^{tm1.1(Ncre)Mdes} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253250
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Pvalb^{tm1.1(Ncre)Mdes} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pvalb (MGI:97821)

• Mutation details: Mice were generated by inserting a 2A sequence, the N-terminal fragment of cre recombinase (aa 19-59) fused to the intein-N peptide fragment (123 N terminal amino acids of the DnaE split intein sequence) and Frt-flanked PGK-neomycin resistance cassette immediately in front of the stop codon of parvalbumin coding sequence by homologous recombination. The Frt-flanked PGK-neomycin resistance cassette was removed by crossing with transgenic mice expressing Flpo. (J:253250)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pvalb (mouse) Summary of all recombinase alleles driven by Pvalb. Alliance mouse Pvalb gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pvalb Mutation: 29 strains or lines available

References

• Original: J:253250 Bellavance MA, et al., Parallel Inhibitory and Excitatory Trigemino-Facial Feedback Circuitry for Reflexive Vibrissa Movement. Neuron. 2017 Aug 2;95(3):673-682.e4
• All: 2 reference(s)