Pcp4^tm1.1Kzy
Targeted Allele Detail

Summary

• Symbol: Pcp4^tm1.1Kzy
• Name: Purkinje cell protein 4; targeted mutation 1.1, Kazuhiro Yamakawa
• MGI ID: MGI:6113653
• Gene: Pcp4 Location: Chr16:96268806-96326993 bp, + strand Genetic Position: Chr16, 56.97 cM
• Alliance: Pcp4^tm1.1Kzy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:241597
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed exon 1 and neomycin resistance cassette were deleted via Cre-mediated recombination. Amplification and sequencing of a 423 bp fragment overlapping exon 1 confirmed its deletion. Immunolabeling confirmed no protein in the adult homozygous brain. (J:241597)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcp4 Mutation: 7 strains or lines available

References

• Original: J:241597 Raveau M, et al., Brain ventriculomegaly in Down syndrome mice is caused by Pcp4 dose-dependent cilia dysfunction. Hum Mol Genet. 2017 Mar 01;26(5):923-931
• All: 2 reference(s)