Tg(Mrc1-cre/ERT2)#Tobe
Transgene Detail

Summary

• Symbol: Tg(Mrc1-cre/ERT2)#Tobe
• Name: transgene insertion, Kazuyuki Tobe
• MGI ID: MGI:6113806
• Synonyms: CD206-CreER^T2
• Transgene: Tg(Mrc1-cre/ERT2)#Tobe Location: unknown
• Alliance: Tg(Mrc1-cre/ERT2)#Tobe page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Mrc1-cre/ERT2)#Tobe expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mrc1 (MGI:97142)

• Mutation details: The 152 kb BAC clone (RP24-377D19) containing the exon coding translational start codon and upstream 133 kb sequence of mouse Mrc1 (CD206) gene was modified by introducing noncoding exon and intron from rabbit b-globulin gene, cre/ERT2, and rabbit b-globulin and simian virus 40 polyadenylation (pA) signal into the BAC. Line numbers were not indicated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:252768)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mrc1 (mouse) Summary of all recombinase alleles driven by Mrc1. Alliance mouse Mrc1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:252768 Nawaz A, et al., CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors. Nat Commun. 2017 Aug 18;8(1):286
• All: 2 reference(s)