Gatm^em1Btlr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gatm^em1Btlr
• Name: glycine amidinotransferase (L-arginine:glycine amidinotransferase); endonuclease-mediated mutation 1, Bruce Beutler
• MGI ID: MGI:6113823
• Synonyms: Gatm^c
• Gene: Gatm Location: Chr2:122424954-122441758 bp, - strand Genetic Position: Chr2, 60.63 cM
• Alliance: Gatm^em1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR targeting was used to generate a frameshift mutation (3 bp deleted, 2 bp inserted) at the transcription start site. (J:252049)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gatm Mutation: 22 strains or lines available

References

• Original: J:252049 Turer E, et al., Creatine maintains intestinal homeostasis and protects against colitis. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1273-E1281
• All: 1 reference(s)