Dock2^m7Btlr
Chemically induced Allele Detail

Summary

• Symbol: Dock2^m7Btlr
• Name: dedicator of cyto-kinesis 2; mutation 7, Bruce Beutler
• MGI ID: MGI:6114020
• Synonyms: denali
• Gene: Dock2 Location: Chr11:34176815-34674719 bp, - strand Genetic Position: Chr11, 19.68 cM, cytoband A5
• Alliance: Dock2^m7Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 34,229,472 (v38) on chromosome 11, or base pair 554,438 in the GenBank genomic region NC_000077 for the gene within the donor splice site of intron 50. The effect of the mutation at the cDNA and protein level have not examined, but the mutation is predicted to result in skipping of the 121-nucleotide exon 50 (out of 52 total exons), resulting in a frame-shifted protein product beginning after amino acid 1,720 in the coded protein and premature termination after the inclusion of 20 aberrant amino acids. (J:255181)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dock2 Mutation: 143 strains or lines available

References

• Original: J:255181 Yue T, et al., Mutagenetix entry for denali. MGI Direct Data Submission. 2018
• All: 1 reference(s)