Msh6^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Msh6^m1Btlr
• Name: mutS homolog 6; mutation 1, Bruce Beutler
• MGI ID: MGI:6114079
• Synonyms: medea
• Gene: Msh6 Location: Chr17:88282490-88298320 bp, + strand Genetic Position: Chr17, 57.87 cM
• Alliance: Msh6^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to A transition at base pair 87,980,223 (v38) on chromosome 17, or base pair 5,174 in the GenBank genomic region NC_000083. The mutation corresponds to residue 389 in the mRNA sequence NM_010830 within exon 2 of 10 total exons. The mutation results in substitution of tryptophan (W) 97 for a premature stop codon (W97*) in the protein. (J:255208)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Msh6 Mutation: 52 strains or lines available

References

• Original: J:255208 Yue T, et al., Mutagenetix entry for medea. MGI Direct Data Submission. 2018
• All: 1 reference(s)