Myo15a^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Myo15a^m2Btlr
• Name: myosin XVA; mutation 2, Bruce Beutler
• MGI ID: MGI:6114085
• Synonyms: typhoon
• Gene: Myo15a Location: Chr11:60360165-60419195 bp, + strand Genetic Position: Chr11, 37.81 cM
• Alliance: Myo15a^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to A transition at base pair 60,487,425(v38) on chromosome 11, or base pair 113,685 in the GenBank genomic region NC_000077; the mutation is within the donor splice site of intron 10. The effect of the mutation at the cDNA and protein level have not examined, but the mutation is predicted to result in the use of a cryptic site in intron 10, resulting in a transcript that has an 8-base pair insertion on intron 10. This predicts a frame shifted protein product beginning after amino acid 1,386 of the protein, which is normally 3,511 amino acids in length, and terminating after the inclusion of 23 aberrant amino acids. (J:255209)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo15a Mutation: 136 strains or lines available

References

• Original: J:255209 Prince L, et al., Mutagenetix entry for typhoon. MGI Direct Data Submission. 2018
• All: 1 reference(s)