Nlrp3^M11Btlr
Chemically induced Allele Detail

Summary

• Symbol: Nlrp3^M11Btlr
• Name: NLR family, pyrin domain containing 3; mutation 11, Bruce Beutler
• MGI ID: MGI:6114093
• Synonyms: Park8
• Gene: Nlrp3 Location: Chr11:59432395-59457781 bp, + strand Genetic Position: Chr11, 37.73 cM, cytoband B1.3
• Alliance: Nlrp3^M11Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to C transversion at base pair 59,566,199 (v38) on chromosome 11, or base pair 24,631 in the GenBank genomic region NC_000077. The mutation corresponds to residue 3,264 in the mRNA sequence NM_145827 within exon 10 of 10 total exons. The mutation results in an arginine to proline substitution at position 1,013 (R1013P) in the protein. (J:255211)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp3 Mutation: 64 strains or lines available

References

• Original: J:255211 Shi H, et al., Mutagenetix entry for Park8. MGI Direct Data Submission. 2018
• All: 1 reference(s)