Prkdc^m4Btlr
Chemically induced Allele Detail

Summary

• Symbol: Prkdc^m4Btlr
• Name: protein kinase, DNA activated, catalytic polypeptide; mutation 4, Bruce Beutler
• MGI ID: MGI:6114123
• Synonyms: screamer3
• Gene: Prkdc Location: Chr16:15455730-15660099 bp, + strand Genetic Position: Chr16, 10.09 cM, cytoband B1
• Alliance: Prkdc^m4Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 15,740,332 (v38) on chromosome 16, or base pair 102,890 in the GenBank genomic region NC_000082 within the donor splice site of intron 51. The effect of the mutation at the cDNA and protein level have not examined, but the mutation is predicted to result in skipping of the 132-nucleotide exon 51 (out of 86 total exons), resulting in an in-frame deletion of 44 amino acids beginning after amino acid 2,250 of the protein, which is normally 4128 amino acids long. (J:255217)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkdc Mutation: 418 strains or lines available

References

• Original: J:255217 Zhong X, et al., Mutagenetix entry for screamer3. MGI Direct Data Submission. 2018
• All: 1 reference(s)