Rims4^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Rims4^m2Btlr
• Name: regulating synaptic membrane exocytosis 4; muation 2, Bruce Beutler
• MGI ID: MGI:6114733
• Synonyms: diminutive
• Gene: Rims4 Location: Chr2:163701671-163760603 bp, - strand Genetic Position: Chr2, 84.52 cM
• Alliance: Rims4^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced G to A transition at base pair 163,864,865 (v38) on chromosome 2, or base pair 54,126 in the GenBank genomic region NC_000068 within the donor splice site of intron 5. The effect of the mutation at the cDNA and protein level have not examined, but the mutation is predicted to result in the use of a cryptic splice site in exon 5. The use of a cryptic splice site would result in a transcript with a 42-base pair deletion in exon 5 and an in-frame deletion of 14 amino acids (amino acids 185-198). (J:255289)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rims4 Mutation: 37 strains or lines available

References

• Original: J:255289 SoRelle J, et al., Mutagenetix entry for diminutive. MGI Direct Data Submission. 2018
• All: 1 reference(s)