Coq3^em1(IMPC)J
Endonuclease-mediated Allele Detail

Summary

• Symbol: Coq3^em1(IMPC)J
• Name: coenzyme Q3 methyltransferase; endonuclease-mediated mutation 1, Jackson
• MGI ID: MGI:6114793
• Gene: Coq3 Location: Chr4:21879673-21912162 bp, + strand Genetic Position: Chr4, 9.11 cM
• Alliance: Coq3^em1(IMPC)J page
• IMPC: Coq3 gene page

Mutation origin

• Strain of Origin: C57BL/6NJ
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at The Jackson Laboratory by injecting Cas9 RNA and 4 guide sequences GTATTGCAAATGATAAGCAA, GAGTTTCTTTGGGATAACAA, GAGTTTCTTTGGGATAACAA and CCAGTATGTTAAAGCTTATG, which resulted in a 559 bp deletion beginning at Chromosome 4 positive strand position 21,892,681 bp and ending after 21,893,239 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000340164 (exon 2) and 432 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 36 and early truncation 42 amino acids later. (J:188991)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Coq3 Mutation: 21 strains or lines available

References

• Original: J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012
• All: 3 reference(s)