Tg(CAG-cat,-ALOX15)1868Klv
Transgene Detail

Summary

• Symbol: Tg(CAG-cat,-ALOX15)1868Klv
• Name: transgene insertion 1868, Uddhav P Kelavkar
• MGI ID: MGI:6114990
• Synonyms: REAGENT, Reagent Mouse-1
• Transgene: Tg(CAG-cat,-ALOX15)1868Klv Location: unknown
• Alliance: Tg(CAG-cat,-ALOX15)1868Klv page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-cat,-ALOX15)1868Klv expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Alox15 (MGI:87997)

• Mutation details: The transgene consists of the CAG promoter consisting of a cytomegalovirus enhancer and a chicken beta-actin promoter, a loxP flanked chloramphenicol acetyl-transferase (cat) reporter gene with stop codons at the 3' end and human 15-lipoxygenase-1 cDNA. In the absence of Cre-recombination, the CAG promoter drives the expression of the cat reporter gene but not ALOX15. When Cre-mediated recombination removes the floxed cat reporter, CAG drives the expression of human ALOX15. Three lines were established: 1857, 1863, 1868. (J:114903)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:114903 Kelavkar UP, et al., Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model. Neoplasia. 2006 Jun;8(6):510-22
• All: 1 reference(s)